Marie Dehem, the new SeqOne EMEA Sales & Business Manager precision Medicine, Oncology

We are very pleased to announce the appointment of Marie Dehem to the role of EMEA sales & business manager Precision Medicine, Oncology. Marie is molecular biologist specialized in oncology. She spent several years as researcher before working as business manager and country manager for more than 15 years in several biotech companies (Genoscreen, DNA vision, GATC Biotech and OncoDNA).

“I am delighted to join SeqOne Genomics to expand its business internationally and reinforce its role as a key player in Precision Medicine.” Ms. Dehem stated. “I’m pleased to bring my expertise and network in oncology to this fast-growing company”

Myriam Guiral, the new SeqOne CCO EMEA & Biopharma Head

We are very pleased to announce the appointment of Myriam Guiral to the role of CCO EMEA & Biopharma Head. Myriam has more than 20 years of global sales and general leadership experience that will be critical to the commercial development of SeqOne Genomics. Prior to joining SeqOne, Myriam led OncoDNA’s global commercial team and before that held leadership roles at IQVIA, GE Healthcare, Abbott Diagnostics and Becton Dickinson.

‘’I am really proud to take on a leadership commercial role at this exciting time for SeqOne Genomics as it accelerates its global expansion. The company’s genomics analysis platform is well established in France and poised for international expansion. I will also spearhead the company’s new genomic analysis solution for pharmaceutical and biotech industries.‘’ said Myriam.

Using molecular clocks to tell cancer time

We all know tracking metastatic cancer progression is vital for ongoing monitoring of cancer patients, but how do metastatic cancers arise in the first place? Are they seeded simultaneously throughout the body, or do they arise progressively? How are they related to the original tumour? More importantly, how do different metastases respond to treatment, and how can we track this? Amazingly, new insights from the UK’s LEGACY breast cancer program is shedding light on some of these important questions! 

This study simultaneously examined biopsies of primary and secondary tumours from two breast cancer donors, which revealed that secondary tumours were predominantly seeded from a single cell lineage of the primary tumour. This indicates a remarkable phenomenon of monoclonal seeding for metastatic breast cancers, which also aligns with previous studies showing the same progression in colorectal cancers. 

The good news is that if cancer metastases are clonal, the ability to track their dissemination and dynamics becomes more plausible. As a first step to prove this, scientists in this study used chemical markers that progressively accumulate in DNA, serving as molecular clocks to lineage trace metastatic cancers as they spread to secondary sites. These markers can be used for metastatic cancer monitoring by charting secondary cancer ‘family trees’ for each patient. 

Next, they leveraged an easily available resource: circulating tumour DNA in blood samples from breast cancer patients. The specific molecular clock markers found in tissue samples from primary or secondary tumour biopsies were found to correlate highly with their frequency of occurrence in plasma tumour DNA. 

This is very encouraging, as it opens up a range of possibilities for following cancer progression using regular blood tests. First, metastases formation can be closely monitored, and their evolutionary lineages can be traced to the original tumour using these molecular clocks, which could point to initial treatment options. Secondly, relative pathogenic impacts of secondary tumours can also be assessed by monitoring levels of their lineage-specific molecular markers in the blood. Finally, the responses of the various metastatic tumours to different therapies can be tracked, providing the doctors with valuable real-time information that can be effectively used to optimise personalised medical treatment for each patient.

We are very excited by ongoing genomics research to develop new ways of monitoring cancer evolution, pathogenicity, and treatment outcomes using the relatively simple process of blood biopsies which will deliver better options for patients. SeqOne will continue to closely monitor progress in this rapidly growing field to enable seamless incorporation of these new techniques into our software platform for enhanced clinical outcomes.

Original article: https://www.nature.com/articles/s41467-020-15047-9

A French start-up harnesses the power of the latest generation genomic sequencers to dramatically increase COVID 19 testing capacity

SeqOne Genomics, a start-up specialized in genomic analysis software, is partnering with leading medical testing labs to develop an approach that delivers up to 100 times more COVID 19 tests per machine thanks to NGS sequencers.

Montpellier: May 1st, 2020: Epidemiological experts agree that the key to successfully managing the COVID 19 pandemic is a robust national testing capability that can dispense hundreds of thousands of tests per day.  Yet governments have struggled to ramp their testing capabilities to meet this vital objective. The cause of the testing shortfall is that the most reliable tests involve identifying the genetic signature of the virus using a mature qPCR technology that can only process a small number of tests per machine.  Clearly, satisfying the need for high volume national COVID-19 testing will require innovative new approaches that can scale to deliver substantially more tests than existing qPCR technology.  

SeqOne Genomics, a French start-up specialized in genomic analysis software, is developing a new approach to testing that could achieve this objective.  The approach takes advantage of the power of the latest generation of high throughput NGS sequencers to deliver tens of thousands of tests at a time.  To harness the power of these new machines, the company has developed software that incorporates concepts seen in academic publications in areas including multiplexing and extraction-free sequencing to allow large numbers of patient samples to be pooled together for analysis while keeping track of each individual’s results.  “Using NGS sequencers made sense both because of their power and availability,” said Nicolas Philippe, CEO of SeqOne Genomics. “We focused on developing a software solution that made it possible to use them to deliver high volumes of tests in a clinical environment” 

The concept has been successfully tested in the lab showing accuracy comparable to qPCR tests.  The approach offers the added benefit of providing information on an infected person’s viral load which can help optimize treatment strategies and better understand the disease from an epidemiological perspective.  Supported by the French government, SeqOne is now working with some of France’s largest medical testing labs and computing infrastructure providers to implement the concept nationwide.   

With implementation in France underway, SeqOne is now turning its sights on other countries and markets that might benefit from a cost-effective way to increase their testing capabilities.

About SeqOne: SeqOne develops state-of-the-art genomics analysis tools for clinical applications in the fields of cancer and rare disease. Its flagship product, SeqOne | Platform is a cloud-based end-to-end solution that dramatically reduces the turnaround time and cost required to deliver accurate genetic analyses for use in mainstream medicine.  In the short time since it has launched its platform secured a wide user base in a diver range of healthcare establishments including hospitals and private sector testing labs. It has won numerous awards including the prestigious iLab award and the ARC cancer foundation’s Hélène Stark prize. SeqOne is supported by the SATT AxLR and the Montpellier BIC incubator. 

Tests du Covid-19 : une startup française s’allie avec les leaders industriels pour contribuer à l’augmentation massive de la capacité nationale de dépistage

Un dépistage massif et précis est l’une des armes incontournables dans la lutte contre le Covid-19. Tous les experts s’accordent en effet sur l’urgence et l’absolue nécessité d’augmenter notre capacité à dépister  afin de gérer efficacement le déconfinement et d’enrayer la propagation du virus.

L’enjeu : dépasser les 100 000 tests par jour

Le gouvernement français s’est fixé l’objectif ambitieux de réaliser 100 000 tests par jour d’ici la mi-mai (contre quelques milliers au début de la crise) afin d’enclencher et d’accompagner le processus de déconfinement de la population. Les tests les plus fiables utilisent la technologie qPCR qui permet d’identifier la présence du virus mais qui ne permet de tester qu’un faible nombre de patients par machine. L’utilisation de technologies plus puissantes et disruptives pourra contribuer à cette augmentation massive et rapide des capacités.

 Associer big-data et séquençage NGS pour accroitre les capacités de dépistage

La société SeqOne, startup française DeepTech, s’est entièrement mobilisée sur ce front et propose une nouvelle solution qui exploite les capacités de la dernière génération d’appareils d’analyse génomique à très haut débit. Cette nouvelle génération de séquençage (Next-Generation Sequencing ou NGS) alliée à une technique innovante de multiplexage permet désormais  d’accroitre significativement les capacités de dépistage en simultané et par machine.  La qualité des tests sera elle aussi améliorée grâce à la mesure de la charge virale. Elle  pourrait permettre ainsi un suivi épidémiologique national, enjeu majeur pour la gestion de la crise à court terme, du déconfinement et des phases qui suivront à plus long terme.

Une collaboration startup, industrie et recherche académique pour  valider cette solution et mettre en place les conditions de son déploiement au niveau national

La recherche dans son ensemble se mobilise pleinement depuis l’apparition du virus. La coopération entre la recherche publique et privée doit permettre d’élaborer des solutions afin d’accompagner le déconfinement et d’enrayer durablement l’épidémie.  

La solution a passé avec succès la phase de validation technique, tant en quantité (efficacité du multiplexage) qu’en qualité (détection précise de charge virale).  SeqOne travaille désormais à industrialiser ces tests afin de les rendre disponibles au niveau national en partenariat avec les principaux laboratoires de test médicaux et des pouvoirs publics et avec le soutien de la SATT AxLR.  Compte tenu de l’enjeu et du volume de données engendrées, la société a noué un partenariat avec OVHcloud garantissant la souveraineté des données grâce à sa solution HDS (Hébergement de Données de Santé). 

Cette avancée illustre la capacité d’innovation nationale et nous donne l’espoir d’une nouvelle solution qui pourrait être opérationnelle rapidement.

A propos de SeqOne :  SeqOne, société de bio-informatique basée à Montpellier, développe des outils d’analyse génomique de pointe pour des applications cliniques dans les domaines du cancer et des maladies rares. Son produit phare, SeqOne | Platform, est une solution de bout en bout basée sur le Cloud qui réduit considérablement les délais et les coûts nécessaires pour fournir des analyses génétiques précises destinées à la médecine traditionnelle.  En peu de temps depuis le lancement de sa plate-forme, elle a sécurisé une large base d’utilisateurs dans un large éventail d’établissements de soins de santé, y compris des hôpitaux et des laboratoires de tests du secteur privé. Elle a remporté de nombreux prix, dont le prestigieux prix iLab et le prix Hélène Stark de l’ARC Cancer Foundation. SeqOne est soutenu par la SATT AxLR, l’incubateur BIC de Montpellier Méditerranée Métropole, l’Université de Montpellier, l’INSERM, la région Occitanie, ainsi que les banques Caisse d’Épargne et Banque Populaire.

EUROFINS BIOMNIS AND SEQONE PARTNER TO IMPROVE CLINICAL ACCESS TO WHOLE EXOME TESTING

Eighty percent of rare diseases are genetic in origin and result from a small number of genetic mutations. Identifying these variations is essential in diagnosing the diseases and can dramatically improve patient care.

Making Whole Exome sequencing more affordable to improve diagnostic efficiency

Since 2017, Eurofins Biomnis has offered “Whole Exome” sequencing which, starting from a simple blood test, provides information on all the genes relevant to a diagnosis. Using Whole Exome sequencing more than 30% of patients can be diagnosed with a single. Test, which represents a significant improvement over traditional gene panel approaches that result in diagnoses in only 10% -15% of cases.


Until now and despite its superior performance, the use of “Whole Exome” sequencing has been limited. Obstacles have included the high costs, as well as the limited availability of adequate scientific, clinical and technical means, necessary to identify the causal mutation among the tens of thousands of mutations detected in “Whole Exome” sequencing.

Harnessing artificial intelligence to better identify and interpret mutations

The partnership between Eurofins Biomnis and SeqOne combines best-in-class sequencing with the most efficient tools to facilitate the interpretation of the results. Thanks to this, a detailed report of the results to be obtained in under six weeks.

Whole Exome sequencing generates on average 200 GB of raw data and reveals tens of thousands of mutations. The SeqOne platform uses artificial intelligence techniques to explore academic research databases and cross-reference this information with the test results. This allows the platform to automatically rank each patient’s mutations in order of diagnostic relevance thus helping to identify the right diagnosis. The easy-to-use cloud-based system offers biologists and clinicians the most effective genomic interpretation tool on the market. “SeqOne was designed to make the most complex genetic analysis accessible to as many people as possible,” said Nicolas Philippe, CEO of SeqOne.

Dr Ines Harzallah of the chromosomic molecular genetics service of CHU Saint-Etienne explains the advantages of having access to a high performance genomic interpretation platform like SeqOne thus:
“We are convinced that Whole Exome sequencing will help improve our diagnostics. Nevertheless, this test is complex and expensive today. The Eurofins Biomnis/SeqOne combined offer provides. an excellent quality of sequencing coupled with an intuitive bioinformatics analysis notably thanks to the automatic help in the classification of variants and all at an attractive price. Our experience shows that, in practical terms, it saves precious time”.

Do-it-yourself or collaborative variant interpretation options available
When a healthcare professional requests a Whole Exome analysis from Eurofins Biomnis, they automatically have access to the SeqOne platform, at no additional cost. There are three options for interpreting the results:

  • interpretation of the variants by Eurofins Biomnis,
  • a joint interpretation carried out with a Eurofins Biomnis biologist, or
  • interpretation of the data independently.

The co-interpretation model that ensures optimal diagnostic yield because it combines the scientific knowledge of Eurofins Biomnis biologists specializing in genetics with that of the clinician. For Laure Raymond, the Eurofins Biomnis biologist responsible for Whole Exome test and interpretation, “the partnership with SeqOne is part of Eurofins Biomnis’ strategy to actively involve clinicians in the interpretation of exomes ”.

The number of patients without diagnosis is reduced and clinicians have the opportunity to grow their expertise in genomic medicine thanks to the intuitive SeqOne interpretation tool and interaction with our experts.
Thanks to its logistics network, Eurofins Biomnis is able to guarantee patients and the medical profession availability of this medical test anywhere in France with more countries slated to come onstream soon.

About Eurofins Biomnis
European leader in the medical biology sector, Eurofins Biomnis performs more than 32,000 analyses per day from a catalogue of over 2,500 examinations, including specialized procedures for which it has all the necessary approvals. Founded in 1897 by Marcel Mérieux, Eurofins Biomnis remains the reference in specialized biology in France thanks to its commitment to innovation and investments in technology, particularly in the fields of women’s biology, oncology, personalized medicine and chromosomal and molecular genetics. With one hundred and twenty years of expertise and innovation in medical biology, the European platform of the Clinical Diagnostics division of the Eurofins Group, Eurofins Biomnis continues to develop internationally. www.eurofins-biomnis.com

Eurofins Biomnis press contact
Agence Wellcom
Natacha Kalasa, Gaëlle Ryouq, Héloïse Sintes
biomnis@wellcom.fr
+33 1 46 34 60 60

About SeqOne:
SeqOne develops state-of-the-art genomics analysis tools for clinical applications in the fields of cancer and rare disease. Its flagship product, SeqOne | Platform is a cloud-based end-to-end solution that dramatically reduces the turnaround time and cost required to deliver accurate genetic analyses for use in mainstream medicine. In the short time since it has launched its platform secured a wide user base in a diver range of healthcare establishments including hospitals and private sector testing labs. It has won numerous awards including the prestigious iLab award and the ARC cancer foundation’s Hélène Stark prize. SeqOne is supported by the SATT AxLR and the Montpellier BIC incubator.
For more information: https://seqone.com

SeqOne press contact
Jean-Marc Holder
Tel : +33 6 03 24 57 56
Mel : jm.holder@seqone.fr